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Original Research Article | OPEN ACCESS

Apigenin exerts anticancer effects on human cervical cancer cells via induction of apoptosis and regulation of Raf/MEK/ERK signalling pathway

Jie Yang1, Jing Fa2, Bingxing Li3

1Women's Health, HealthCare Hospital of Linyi; 2Department of Gynaecology, Linyi City Tumor Hospital; 3Department Obstetrical, Health Care Hospital of Linyi, Linyi, Shandong 276000, China.

For correspondence:-  Bingxing Li   Email: bingxingli@hotmail.com   Tel:+86138539881132

Accepted: 24 July 2018        Published: 31 August 2018

Citation: Yang J, Fa J, Li B. Apigenin exerts anticancer effects on human cervical cancer cells via induction of apoptosis and regulation of Raf/MEK/ERK signalling pathway. Trop J Pharm Res 2018; 17(8):1615-1619 doi: 10.4314/tjpr.v17i8.21

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the anticancer activity of apigenin on human cervical cancer cells.
Methods: The anti-proliferative effects of apigenin on HeLa cervical cancer cells were determined by 3-(4,5-dimethylthiazol-2-yl)- )-2,5-diphenyltetrazolium bromide (MTT) and clonogenic assays, while its effect on apoptosis was assayed by DAPI and annexin V/PI double staining. expression of proteins was assessed by immunoblotting.
Results: Apigenin exerted anticancer effects on HeLa cervical cancer cells with an IC50 of 15 µM, and also reduced the colony formation of HeLa cells. These antiproliferative effects were due to induction of apoptosis as indicated by DAPI and annexin V/PI staining. Apigenin altered Bax/Bcl-2 ratio, thereby triggering apoptosis, and also inhibited the Raf/MEK/ERK signalling pathway.
Conclusion: These results indicate that apigenin suppresses the growth of cervical cancer cells and may prove to be an important molecule for the treatment of cervical cancer.

Keywords: Cervical cancer, Apigenin, Apoptosis, Bax

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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